UniProtKB/Swiss-Prot PTM Description

(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus

N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR) Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation

Glycosylation Sites

Position Structures Description Evidence
ASN-727 Associated Structures: 7 global GlycoSuite
Position Structures Description Evidence
THR-104 Associated Structures: 12 global GlycoSuite
Site-Specific Information

A number of glycan structures have been assigned to specific glycosylation sites

Position Structures Description Evidence
ASN-727 Associated Structures: 7 Site specific GlycoSuite
THR-104 Associated Structures: 4 Site specific GlycoSuite
ASN-251 Associated Structures: 1 Site specific GlycoSuite
ASN-727 Associated Structures: 1 Site specific GlycoSuite
ASN-317 Associated Structures: 1 Site specific GlycoSuite

Notes

Accompanying information

  1. ASN-727 [HAYES ET AL. (1995) GLYCOBIOLOGY 5:227-232
  2. ASN-251
  3. ASN-727
  4. ASN-317

Structure Format

CFG/Essentials Text Oxford

Sequence

MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF

References showing top 5 6

  1. Presence of O-linked oligosaccharide on a threonine residue in the human transferrin receptor.

    Do S, Cummings R

    PubMed: 1421756 Year: 1992

  2. Human transferrin receptor contains O-linked oligosaccharides.

    Do S, Enns C, Cummings R

    PubMed: 2403553 Year: 1990

  3. Structure of the N-linked oligosaccharides of the human transferrin receptor.

    Orberger G, Geyer R, Stirm S, Tauber R

    PubMed: 1555586 Year: 1992

  4. Identification of the O-linked glycosylation site of the human transferrin receptor.

    Hayes G, Enns C, Lucas J

    PubMed: 1421757 Year: 1992

  5. Structure of human transferrin receptor oligosaccharides: conservation of site-specific processing

    Hayes GR, Williams AM, Lucas JJ, Enns CA.

    PubMed: 9136890 Year: 1997

  6. See more references
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