Associated Structures
Accession: P0C0L4 UniProtKB/Swiss-Prot Entry
UniProtKB/Swiss-Prot PTM Description
Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes
Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. The proteolytic cleavages often are incomplete so that many structural forms can be found in plasma N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan
Glycan Structures
Notes
Accompanying information
Sequence
Biological Associations
Taxonomies
- Homo sapiens >
Protein
- Complement C4-A
- Homo sapiens >
Taxonomies
- Complement C4-A